|
KMID : 0370220000440060595
|
|
Yakhak Hoeji
2000 Volume.44 No. 6 p.595 ~ p.600
|
|
|
Effect of L-Menthol on the Percutaneous Absorption of Ketorolac Tromethamine Across Human Cadaver Skin
|
|
이용석/Lee, Young Seok
오흥설/김하형/이광표/Oh, Heung Seol/Kim, HaHyung/Lee, Kwang Pyo
|
|
|
Abstract
|
|
|
|
Transdermal delivery of ketorolac tromethamine, a potent non-narcotic analgesic, through human cadaver skin was investigated in vitro. A mixture of ethanol/water (40/60) containing 0, 1, 3, 5, and 8 (w/v)% L-menthol were used as a vehicle and penetration enhancer respectively. The permeation of ketorolac through human cadaver skin from saturated drug solution was evaluated at 37?C with modified Franz diffusion cell. The in vitro skin flux and lag time were 1.23±0.11μg/cm2?hr and 5.56±0.34hr, respectively. The cumulative amount of penetrated ketorolac containing L-menthol in ethanol/water (40/60) binary system was increased by the following order; 3%, 5%, 8%, 1%, 0%, and the lag time was decresed by the following order; 3%, 5%, 8%, 0%, 1%. The results suggested that a potential use of 3% L-methol is an effective penetration enhancer of ketorolac tromethamine through the human cadaver skin.
|
|
|
KEYWORD
|
|
|
Ketorolac tromethamine, enhancer, L-menthol, skin permeation rate, cadaver skin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|